When recording multiple guitars on a composition, I often find using different amps on different tracks helpful. This is because guitars are very midrange-heavy instruments. The more guitars you layer on top of each other, the more muddy things can become.

Each part can lose its identity when you start layering the same sound on top of the same sound. So I often try different guitars and amps to help each guitar part stand out as a multi-guitar layered track.

I often see guitarists switch to another pedal on their pedalboard, but in my opinion, that doesn't change the sonic imprint enough, and stacked guitars can still lose their identity.

The best way to carve out some sonic space if stacked guitars are getting a little cluttered is to use a different guitar, amp, or both.